Fri Aug 22 2025

163 articles - From Friday Aug 15 2025 to Friday Aug 22 2025

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastroenterology

AGA Clinical Practice Update on Management of Hepatitis Delta: Commentary.

The purpose of this American Gastroenterological Association (AGA) Clinical Practice Update is to facilitate understanding and improve clinical management of patients with hepatitis delta virus infection. This commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Gastroenterology.

Pubmed   Journal   ReadQx 

Unmasking Treatment Efficacy: A Consensus Blueprint for Steroid Stewardship in IBD Trials.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Enteral stent placement for benign and malignant disease.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies.

Heterogeneity and potential for bias indicates that findings should be interpreted with caution. Standardised protocols to ensure robust methodology and allow pooling of large-scale data are required before these findings can be used in clinical practice (PROSPERO CRD42023431977).

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment.

Through 5 years, rates of virologic suppression were high in East Asian patients treated with TAF or switched from TDF to TAF. TAF and TDF were well tolerated, with improved renal and bone safety observed in patients switching from TDF to TAF.

Pubmed   Journal   ReadQx 

MetALD: Diagnosis and Prognosis With Non-Invasive Tests.

Widely available NITs are applicable for MetALD, where cut-offs can be used to diagnose advanced fibrosis and predict clinical outcomes.

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Avoidant/restrictive eating in people with and without bowel symptoms in the general population: Prevalence, Clinical Profile and Associated Factors.

Avoidant/restrictive eating is common in individuals with bowel symptoms and associated with a more severe clinical profile, indicating a need to discuss eating behavior with patients. However, avoidant/restrictive eating is also common in individuals in the general population without bowel symptoms.

Pubmed   Journal   ReadQx 

Can symptoms and medical history predict outcomes for hydrogen and methane breath testing?

This large questionnaire study demonstrated that IBS-like symptoms, refractory gastroesophageal reflux symptoms, and skin conditions are associated with outcomes on HMBT. These findings support the use of HMBT in accordance with current clinical guidelines.

Pubmed   Journal   ReadQx 

Increased mortality associated with sarcopenia in inflammatory bowel disease: a long-term prospective cohort study.

Probable and confirmed sarcopenia increase the risk of long-term mortality in IBD patients. Sarcopenia assessment can help risk stratification for prognosis in older IBD patients.

Pubmed   Journal   ReadQx 

Safety of Esophageal Dilation Procedures in Patients on Antithrombotic Therapy: A US Collaborative Network Cohort Study.

DAPT was numerically associated with a higher risk of bleeding, but this did not reach statistical significance. These findings aim to inform the clinical decision-making in pre- and post-procedure management of esophageal dilation procedures.

Pubmed   Journal   ReadQx 

The impact of integrating pelvic MRI at diagnosis on early detection of perianal Crohn's disease in pediatrics.

These patients needed more and earlier perianal surgery and had higher biologic use despite their perianal disease being subclinical. Adding routine MR imaging at time of pediatric CD diagnosis may help inform treatment decisions and improve these outcomes.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Accelerated vs Step-Up Endoscopic Treatment for Pancreatic Walled-Off Necrosis: A Randomized Controlled Trial (ACCELERATE).

(ClinicalTrials. gov, Number NCT05601687).

Pubmed   Journal   ReadQx 

Artificial Intelligence for Quantifying Endoscopic Mucosal Ulceration in Crohn's Disease.

Performance of CVE for CD was similar in the SEAVUE validation cohort. CVE provides a means for automated ulceration and mucosal injury quantitation that shows conceptual agreement with SES-CD and offers new capabilities to improve the granularity and personalization of endoscopic disease assessment in CD.

Pubmed   Journal   ReadQx 

Effect of five dietary emulsifiers on inflammation, permeability, and the gut microbiome: a placebo-controlled randomized trial.

In this double-blind placebo-controlled exploratory trial, emulsifier supplementation lowered SCFA concentration compared to placebo. Emulsifier supplementation did not impact intestinal or systemic inflammation, or metabolic endpoints. Cholesterol levels decreased after two weeks of EFD. These results point towards potential intestinal benefits of limiting dietary emulsifiers in the diet, requiring further investigation.

Pubmed   Journal   ReadQx 

Real-World Experience of Upadacitinib Reinduction and High Dose Maintenance Therapy in Inflammatory Bowel Disease.

Most patients with IBD who lose response to UPA when dose reduced in maintenance can be recaptured with 45mg QD. Among these, continuing 45mg QD for maintenance is effective, and appears safe.

Pubmed   Journal   ReadQx 

Real-time use of computer-aided diagnosis in the optical diagnosis of gastric neoplasia: A multicenter randomized controlled trial.

The present CADx assistance did not improve the non-expert optical diagnosis of gastric neoplasia. Further improvements of the CADx with WLI are needed by changing the confidence level cut-off and additional training on easily missed neoplasias. Another option is CADx with magnifying narrow band imaging. (Japan Registry of Clinical Trials, number jRCTs032210171).

Pubmed   Journal   ReadQx 

Real-world comparison of the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis: the TORUS study.

Tofacitinib and ustekinumab are similarly effective to induce and maintain CFREM after anti-TNF failure in UC. However, tofacitinib could be favored in case of multiple therapeutic failures (≥ 3 biologics) and primary failure to any biologic.

Pubmed   Journal   ReadQx 

Whole-Exome Sequencing-Identified Germline Variants Underlie High Familial Risk and Early-Onset Colorectal Cancer in Taiwan.

These findings improve our understanding of germline genetics in Taiwanese CRC, support better screening and management strategies, and highlight the need to expand Asian variant databases for improved risk assessment and care.

Pubmed   Journal   ReadQx 

Endoscopy

Efficacy of artificial intelligence for adenoma detection in water exchange colonoscopy: A two-center randomized controlled trial.

For WE colonoscopy, integrating CADe statistically increased APC without prolonging the withdrawal time or causing a concomitant increase in non-neoplastic lesion resection.

Pubmed   Journal   ReadQx 

Endoscopic management of refractory gastrointestinal-tracheobronchial fistulas with two novel occluders: a comparative cohort study.

All procedure-related AEs were mild, occurring in five DU (13.9%) and three MU patients (6.0%). The MU occluder showed greater potential for sustained occlusion than the DU occluder and may be a viable option for refractory GI-tracheobronchial fistulas, although further prospective studies are needed.

Pubmed   Journal   ReadQx 

National root-cause analysis of 1724 post-colonoscopy colorectal cancers demonstrates avoidable harm.

This is the largest detailed PCCRC review to date. The majority of PCCRCs were avoidable and caused significant harm. This study clarifies the causes of diagnostic delays and highlights high-risk areas of the colon and high-risk patients, and what needs to be done to reduce PCCRC in the future.

Pubmed   Journal   ReadQx 

Reducing the environmental impact of gastrointestinal endoscopy: a prospective study on waste management through waste segregation and staff education.

Targeted interventions such as staff education and structured waste segregation protocols substantially reduced RMW and associated GHG emissions in a high-volume endoscopy unit. These results suggest that simple, low-cost changes may improve environmental sustainability in clinical practice.

Pubmed   Journal   ReadQx 

STAndardization of Reports (the STAR project) Upper gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.

A suggestion for a normal findings report is provided. Standardized reporting could enhance the quality of UGI endoscopy.

Pubmed   Journal   ReadQx 

Training esophagogastroduodenoscopy skills: a randomized multicenter trial comparing simulation-based training versus clinical training.

SBT prior to CBT reduces the number of supervised procedures required to achieve independent procedural completion without negatively affecting patient satisfaction or increasing training costs. These findings support the routine implementation of SBT when learning EGD.

Pubmed   Journal   ReadQx 

Gastroenterology

Histologic response is associated with improved esophageal distensibility and symptom burden in pediatric eosinophilic esophagitis.

Histologic remission is associated with improved esophageal distensibility over time in pediatric EoE patients. Baseline esophageal distensibility provides a quantitative marker of tissue remodeling and may help predict disease severity and fibrostenotic progression.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Clinical impact of combination of lesion-border findings and pit patterns for identifying invasive versus non-invasive neoplastic lesions in ulcerative colitis.

One hundred and eighteen lesions were classified with distinct borders and 40 with indistinct borders. The diagnostic sensitivity, specificity, and accuracy of type II/III pit patterns were intramucosal, suggesting lesions suitable for endoscopic resection.

Pubmed   Journal   ReadQx 

Clinical utility of suprapapillary plastic stents for lifelong biliary drainage in unresectable malignant hilar biliary obstruction.

SPPS, as the first stent for unresectable MHBO, was considered superior to SEMS for the intermittent maintenance of LBD. Achieving LBD success or extending TLBDF may help preserve therapeutic options.

Pubmed   Journal   ReadQx 

Comparison of endoscopic band ligation versus over-the-scope clip for colonic diverticular bleeding: A propensity score-matched cohort analysis.

No significant differences in initial hemostasis, requirements for IVR or surgery, requirements of red blood cell transfusion, and adverse events were observed between the two groups. OTSC was more effective than EBL for reducing early recurrent bleeding rate in endoscopic hemostasis for CDB.

Pubmed   Journal   ReadQx 

ENDOSCOPIC TUNNELED STRICTUROTOMY VERSUS SURGICAL CONVERSION TO ROUX-EN-Y GASTRIC BYPASS FOR THE MANAGEMENT OF STENOSIS AFTER SLEEVE GASTRECTOMY.

Endoscopic stricturotomy is a safe, effective alternative for refractory post-LSG stenosis.

Pubmed   Journal   ReadQx 

Focused communication Three-dimensional volume estimates of pancreatic fluid collections in relation to clinical outcomes of endoscopic ultrasound-guided treatment.

The maximum diameter represented a comparable model goodness-of-fit. PFC volume was associated with the outcomes of EUS-guided interventions, and the maximum diameter may be a reasonable surrogate.

Pubmed   Journal   ReadQx 

Optimal Interval of Screening Endoscopy for Reducing Gastric Cancer Mortality: A Nationwide Cohort Study.

Patients who underwent screening at intervals ≤3 years had a significantly reduced risk of GC-specific mortality compared to those screened at intervals >3 years. A 3-year screening interval may be an effective strategy for high-risk regions.

Pubmed   Journal   ReadQx 

Performance comparison of quantitative and qualitative fecal immunochemical tests in community-based colorectal cancer screening.

QnFIT exhibited lower positivity, higher DR at colonoscopy and PPV for CRC over qlFIT. Almost half of colonoscopy resources were saved by qnFIT, although adenoma and polyp were missed in population screening.

Pubmed   Journal   ReadQx 

Gut

Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial.

As monotherapy for patients with HBV-HCC, SCG101 demonstrated pronounced antiviral and antitumour activities and a safety profile manageable with supportive care. SCG101's T-cell expansion, serum HBsAg drop and tumour response collectively underscore on-target activity.

Pubmed   Journal   ReadQx 

Global prevalence and gastrointestinal symptom burden of individuals with a history of cholecystectomy.

Cholecystectomy is prevalent worldwide and varies across world regions. A history of this procedure is associated with a higher GI symptom burden, either due to new cholecystectomy-related symptomatic conditions, or persistent DGBI misattributed to biliary disease for which a cholecystectomy was erroneously performed.

Pubmed   Journal   ReadQx 

ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.

ISG15 regulated HSC activation and liver fibrosis in part via the CREB1/TGFβ2/SMAD2 regulatory pathway. Utilisation of ISG15-CREB1 signalling may be a potential therapeutic target for liver fibrosis.

Pubmed   Journal   ReadQx 

Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes.

Donor intrahepatic microbial DNA signature predicts LT outcomes via immune-metabolic modulation. While causality requires further study, these findings position the graft microbiome as a novel biomarker and potential therapeutic target, paving the way for microbiome-informed precision care in transplantation.

Pubmed   Journal   ReadQx 

Mucosal transcriptomic landscape along the small and large intestines in individuals with and without type 2 diabetes.

Our study offers a detailed mapping of the transcriptomic landscape in the human intestinal tract, demonstrating regionalised gene expression profiles tied to critical biological processes. Notable alterations in immune system activity in the large intestine were observed in individuals with T2D. The publicly available database generated from this study ( provides a valuable resource for exploring the mucosal transcriptome along the human intestinal tract.

Pubmed   Journal   ReadQx 

Hepatology

A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis.

Loss of USP53 interaction with MYO5B and its p.(Arg824Cys) variant impaired BSEP trafficking in USP53- and MYO5B-asociated low-GGT intrahepatic cholestasis. These results provide a novel mechanism that underlies USP53-PFIC and implicates USP53 in the pathogenesis of MYO5B-PFIC.

Pubmed   Journal   ReadQx 

CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression.

Moreover, genetic deficiency of CX3CR1 in myeloid cells or pharmacological inhibition of retinol metabolism remarkably attenuated HCC development. We showed that CX3CR1+Ly6C+ macrophages migrate and interact with aHSCs in the peritumoral region where retinoids induce arginase-1 expression in CX3CR1+Ly6C+ macrophages, subsequently depriving CD8+ T cells of arginine and promoting HCC.

Pubmed   Journal   ReadQx   PMC

Distinct immune microenvironment of venous tumor thrombus in hepatocellular carcinoma at single-cell resolution.

TAMs, especially C5aR+ TAMs, were enriched in PVTT. C5aR+ TAMs contribute to the development of PVTT and poor prognosis by reshaping the immunosuppressive environment.

Pubmed   Journal   ReadQx   PMC

Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinoma.

Additionally, MMP9+ tumor-associated macrophages were enriched across IM and MO, which formed cellular niches with regulatory T cells and proliferative/exhausted T cells. Our findings deeply decipher the heterogeneous TMEs between IM and MO, which provide a comprehensive landscape of multifocal HCC.

Pubmed   Journal   ReadQx   PMC

Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant.

Our findings indicate that induced hepatocytes generated from human-induced pluripotent stem cells carrying the TM6SF2-E167K recapitulate the effects observed in human hepatocytes from individuals with the TM6SF2 mutation. This study characterizes an in vitro model that can be used as a platform to identify potential clinical targets and highlights the therapeutic potential of targeting protein misfolding to alleviate ER stress and mitigate the detrimental effects of the TM6SF2-E167K mutation on hepatic lipid metabolism.

Pubmed   Journal   ReadQx   PMC

Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis.

A cutoff value ≤ 0.43 ng/mL was the optimal rule-out threshold, with a sensitivity of 84.62% (95% CI, 76.46%-90.30%) and a specificity of 79.51% (95% CI, 74.81%-83.53%), while ≥0.50 ng/mL was the best rule-in threshold, with a specificity of 86.41% (95% CI, 81.06%-90.43%) and a sensitivity of 70.67% (95% CI, 64.41%-76.23%). Plasma FSTL-1 has high diagnostic accuracy and could potentially reduce the need for liver biopsy in identifying patients with advanced liver fibrosis.

Pubmed   Journal   ReadQx   PMC

Use of liver stiffness measurement for hepatocellular carcinoma risk stratification in metabolic dysfunction associated steatotic liver disease.

LSM is associated with HCC risk in MASLD. HCC surveillance should be considered in non-cirrhotic MASLD with diabetes and LSM of ≥10 kPa.

Pubmed   Journal   ReadQx 

Value of HCC surveillance in a landscape of emerging surveillance options: Perspectives of a multi-stakeholder modified Delphi panel.

The panel acknowledged performance metrics of emerging methods may differ from other cancer screening programs given differences in populations, including higher risk of cancer development and competing risk of morality, and differences in diagnostic workflow in patients at risk of HCC. These data provide insights into the perceived value of HCC surveillance in an era of emerging blood- and imaging-based surveillance strategies.

Pubmed   Journal   ReadQx 

J Hepatol

Decreased LONP1 expression exacerbates MASH-induced liver fibrosis via elevated orotic acid levels.

Our findings demonstrate that the LONP1-DHODH interaction regulates orotic acid metabolism and alleviates MASH-induced liver fibrosis. Impact and implications Liver fibrosis is one of the main histological determinants of MASH, a disease that parallels the worldwide surge in metabolic syndromes. This study reveals that LONP1 links proteolytic surveillance to mitochondrial metabolic rewiring and regulates orotic acid metabolism, contributing to the progression of MASH-induced liver fibrosis. These findings suggest that targeting orotic acid or hepatocyte LONP1 may represent a promising therapeutic strategy. Further investigation into mitochondrial orotic acid metabolism may yield novel insights into the pathogenesis of liver fibrosis.

Pubmed   Journal   ReadQx 

Identification and validation of RIPK3 as a novel biomarker to predict outcomes in patients with acutely decompensated cirrhosis.

RIPK3-associated cell death is an important driver of organ failure and mortality in AD/ACLF. Integrating plasma RIPK3 into prognostic models would enhance risk stratification and may guide personalised cell death inhibitor therapy in AD/ACLF patients. Impact and implications Our study underscores the pivotal role of Receptor-Interacting Protein Kinase 3 (RIPK3) as a biomarker in acute decompensation (AD) and acute-on-chronic liver failure (ACLF), linking its elevated levels with disease progression, organ dysfunction, and mortality. In liver biopsies, hepatic RIPK1 expression was significantly higher in ACLF than AD and correlated with disease severity and non-survival, supporting their hepatic origin. Through the integration of RIPK3 into predictive models, we provide a path towards personalized therapeutic strategies for AD by targeting necroptosis. This approach has the potential to revolutionize risk stratification, enhance clinical decision-making, and improve outcomes for these high-risk patients.

Pubmed   Journal   ReadQx 

Phase I trial of ADP-A2AFP TCR T-cell therapy in patients with advanced hepatocellular or gastric hepatoid carcinoma.

Lymphodepletion chemotherapy followed by ADP-A2AFP TCR T-cell therapy showed a manageable safety profile and preliminary indications of antitumor activity in these previously treated patients. Impact & implications Adoptive T-cell therapy could be a much-needed additional treatment strategy for advanced hepatocellular carcinoma. Clinicians and researchers interested in the development of adoptive T-cell therapies for advanced solid tumors will be interested to learn that in this phase I trial, ADP-A2AFP T-cell receptor T-cell therapy was associated with an acceptable benefit-to-risk profile and encouraging antitumor activity, illustrating the treatment potential of adoptive T-cell therapy for advanced hepatocellular carcinoma. Clinicaltrials Gov number NCT03132792; first posted 2017-04-08.

Pubmed   Journal   ReadQx 

Proteogenomic profiling predicts outcomes of adjuvant chemotherapy in extrahepatic cholangiocarcinoma.

Here we identified several prognostic and predictive biomarkers that may be useful for guiding adjuvant chemotherapy selection in resected EH-CCA. Further validation is required. Clinicaltrials Gov identifier NCT03079427 IMPACT AND IMPLICATIONS Here we performed comprehensive proteogenomic analyses within a prospective randomized trial of patients with extrahepatic cholangiocarcinoma (EH-CCA). The findings highlighted specific genomic and proteomic alterations that were associated with differential benefit from adjuvant chemotherapy regimens. The integration of multiomics data into a machine learning model provides a practical framework for stratifying patients and guiding treatment decisions, which may inform future clinical trials and biomarker-driven therapeutic strategies.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky.

Pubmed   Journal   ReadQx 

Editorial: Does Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With Advanced Fibrosis Also Equate to Risk of Advanced Coronary Artery Disease?

Pubmed   Journal   ReadQx 

Editorial: Dual Advanced Therapy in Refractory Ulcerative Colitis-Hope Beyond Monotherapy.

Pubmed   Journal   ReadQx 

Editorial: Intestinal Ultrasound for the Assessment of Constipation-Out of the Shadows?

Pubmed   Journal   ReadQx 

Editorial: PSC as an Independent Risk Factor for CRC Without IBD: Can Observed Epidemiological Trends Help Uncover Biological Mechanisms and Guide Surveillance Strategies?

Pubmed   Journal   ReadQx 

Editorial: Redefining Decompensation in Cirrhosis-More Than an Academic Playground?

Pubmed   Journal   ReadQx 

Editorial: Redefining Safety in Post-Liver Transplant IBD-Why Therapeutic Effectiveness Is the Ultimate Shield.

Pubmed   Journal   ReadQx 

Review Article: Impact of Alcohol Consumption on the Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Alcohol amplifies MASLD progression through synergistic mechanisms. Standardised evaluation of alcohol use is critical for risk stratification and the development of personalised treatment strategies.

Pubmed   Journal   ReadQx 

Review Article: Liver Transplantation for Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors.

ICI therapy is nuanced during the peri-transplant period and should therefore be selectively used in specific patients rather than being used ubiquitously.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Biomarker to predict infection and optimize antibiotics use in patients with acutely decompensated cirrhosis: A step in the right direction.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A note from the Editor-in-Chief.

Pubmed   Journal   ReadQx 

An innovative approach to pelvic abscess drainage through a lumen-apposing metal stent: a preliminary retrospective study on a homogeneous sample.

Pubmed   Journal   ReadQx 

EUS-Directed Transgastric Endoscopic Retrograde Cholangiopancreatography in Roux-en-Y Gastric Bypass Anatomy: A Review.

Pubmed   Journal   ReadQx 

Endoscopic necrosectomy: predicting when to step up and when to step off.

Pubmed   Journal   ReadQx 

Optimal stent design in unresectable malignant hilar biliary obstruction: the jury is still out.

Pubmed   Journal   ReadQx 

Redefining the endoscopic retrograde cholangiopancreatography endpoint: a 30-day perspective on patient care.

Pubmed   Journal   ReadQx 

Use of image-enhanced endoscopy to detect gastric premalignant lesions and early gastric cancer: time to leverage artificial intelligence to accomplish this task.

Pubmed   Journal   ReadQx 

Hepatology

Letter to the Editor: Liver stiffness progression comparison between diabetics and non-diabetics with biopsy-proven metabolic dysfunction-associated steatosis.

Pubmed   Journal   ReadQx   PMC

J Hepatol

From long to snappy and short regimens for paracetamol overdose: Reinventing the N-acetyl cysteine wheel.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A rare case of large mucosal poorly differentiated colorectal adenocarcinoma.

Pubmed   Journal   ReadQx 

An Unexpected Outcome of a Giant Hypopharyngeal Lipoma.

Pubmed   Journal   ReadQx 

Endoscopic Submucosal Dissection for Removal of a Deeply Embedded Esophageal Fish Bone Presenting as a Submucosal Tumor.

Pubmed   Journal   ReadQx 

Letter to the Editor.

Pubmed   Journal   ReadQx 

Response to Fang et al.

Pubmed   Journal   ReadQx 

Type 4A Choledochal Cyst with Duodenal Compression.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Esophageal Involvement in Eosinophilic Granulomatosis with Polyangiitis.

Pubmed   Journal   ReadQx 

Oral Contraceptives Significantly Reduce the Risk of Gastroesophageal Reflux Disease, Esophagitis, and Barrett's Esophagus.

Pubmed   Journal   ReadQx 

Real-World Cost Implications of AASLD/AGA MASLD Guidance for Patients with Diabetes, and Factors Associated with Advanced Fibrosis.

Pubmed   Journal   ReadQx 

The mushroom cap sign.

Pubmed   Journal   ReadQx 

URINE PROTEOMICS IN CIRRHOSIS AND ACUTE KIDNEY INJURY: INSIGHTS INTO THE PATHOGENESIS OF HEPATORENAL SYNDROME.

Pubmed   Journal   ReadQx 

Endoscopy

A case of endoscopic combined oval forceps removal of a rectal smooth curved-surface foreign body.

Pubmed   Journal   ReadQx   PMC

A novel technique for large colorectal specimen retrieval after endoscopic submucosal dissection: anoscope-assisted tumor extraction by defecation.

Pubmed   Journal   ReadQx 

A novel technique of B2-B3 single-puncture bridging through liver parenchyma enabling endoscopic ultrasound-guided hepaticogastrostomy for rescue drainage.

Pubmed   Journal   ReadQx   PMC

Aggressive or conservative cyanoacrylate therapy for gastric varices: is more glue better?

Pubmed   Journal   ReadQx 

An anatomically designed duodenal stent with physiological drainage: effective endoscopic rescue in persistent perforation.

Pubmed   Journal   ReadQx   PMC

Artificial intelligence-assisted colonoscopy: excellent results, but will mucosal exposure devices push this boundary?

Pubmed   Journal   ReadQx 

Balloon dilatation method to assist release of the snare trapped in a gastric bezoar.

Pubmed   Journal   ReadQx 

Balloon enteroscope insertion over an endoscopic nasobiliary drainage tube in patients with surgically altered anatomy.

Pubmed   Journal   ReadQx 

Cholangioscope combined with biliary forceps: a novel double-endoscope traction method for rectal endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Closing the gap in endoscopy quality: is artificial intelligence the answer?

Pubmed   Journal   ReadQx 

Closure of a large post-endoscopic full-thickness resection defect in the duodenum using a novel through-the-scope twin clip.

Pubmed   Journal   ReadQx 

Detection by endoscopic ultrasound-guided fine-needle aspiration of retroperitoneal lymph node metastasis as the initial presentation of testicular seminoma.

Pubmed   Journal   ReadQx   PMC

Double aortic arch: a rare cause of adult-onset dysphagia.

Pubmed   Journal   ReadQx 

Endoscopic features of a serrated tubulovillous adenoma in the sigmoid colon.

Pubmed   Journal   ReadQx 

Endoscopic full-thickness resection of an esophageal gastrointestinal stromal tumor without creation of a submucosal tunnel.

Pubmed   Journal   ReadQx   PMC

Endoscopic full-thickness resection: precision and efficacy in treating a giant duodenal stromal tumor.

Pubmed   Journal   ReadQx 

Endoscopic submucosal dissection for early gastric cancer using a novel bending attachment.

Pubmed   Journal   ReadQx 

Endoscopic submucosal dissection of uncommon huge gastric pyloric gland adenoma.

Pubmed   Journal   ReadQx   PMC

Endoscopic suturing with muscular after fundus mucoresection for refractory gastroesophageal reflux disease:a new anti-reflux technique.

Pubmed   Journal   ReadQx   PMC

Endoscopic titanium clip with nylon loop for treating esophageal and gastric variceal bleeding after endoscopic variceal ligation and transjugular intrahepatic portosystemic shunt.

Pubmed   Journal   ReadQx 

Endoscopic ultrasound-guided cyanoacrylate injection for the treatment of gastric variceal bleeding after failed endoscopic embolization.

Pubmed   Journal   ReadQx 

Endoscopic ultrasound-guided drainage of a prevertebral neck abscess: a case report.

Pubmed   Journal   ReadQx   PMC

Enteroscopic direct drainage for submucosal intestinal juice leakage due to afferent loop syndrome in Roux-en-Y anatomy.

Pubmed   Journal   ReadQx 

Esophageal perforation and obstruction during retrieval of gastrointestinal stromal tumor, with final retrieval using laryngoscope.

Pubmed   Journal   ReadQx 

Gastric reactive capillary hemangioma caused by tislelizumab.

Pubmed   Journal   ReadQx   PMC

Hemostasis achieved with new self-assembling peptide hemostatic gel for a bleeding duodenal diverticulum.

Pubmed   Journal   ReadQx 

Intraoperative mixed reality support for endoscopic submucosal dissection of a large laterally spreading tumor in the rectum.

Pubmed   Journal   ReadQx   PMC

Laparotomy and endoscopy cooperative resection in the treatment of Peutz-Jeghers syndrome.

Pubmed   Journal   ReadQx   PMC

Laser-guided rescue: endoscopic removal of complex esophageal foreign bodies.

Pubmed   Journal   ReadQx 

Mixed-reality-based education with holographic support before and during ERCP-related procedures.

Pubmed   Journal   ReadQx   PMC

New peroral pancreatoscopy for direct diagnosis and precise guidewire placement in indeterminate pancreatic duct stricture.

Pubmed   Journal   ReadQx   PMC

Pre-placement sharp angle traction-assisted endoscopic submucosal dissection for the treatment of laterally spreading tumors of the colon.

Pubmed   Journal   ReadQx   PMC

Prototype of a novel cold snare polypectomy device.

Pubmed   Journal   ReadQx 

Quadruple and quintuple transpapillary stenting without predilation for complex hilar biliary obstruction using a novel 7-Fr ultratapered plastic stent.

Pubmed   Journal   ReadQx   PMC

Rarer than rare: managing an epiphrenic diverticulum in achalasia.

Pubmed   Journal   ReadQx 

Recurrent intra-mural esophageal abscess as a complication of untreated eosinophilic esophagitis.

Pubmed   Journal   ReadQx 

Repeat endoscopic submucosal dissection of esophageal squamous cell carcinoma near a previous scar by water pressure method.

Pubmed   Journal   ReadQx 

Secondary endoscopic ultrasound-guided gastroenterostomy to solve stent dysfunction and prolong lifetime in malignant gastric outlet obstruction.

Pubmed   Journal   ReadQx 

Successful resolution of basket impaction in pancreatic stone extraction using endoscopic papillary large balloon dilation.

Pubmed   Journal   ReadQx 

The "garden eel" technique for endoscopic treatment of hepatolithiasis beyond multiple acutely angled sections with strictures.

Pubmed   Journal   ReadQx 

The diagnostic value of confocal laser endomicroscopy in a cancer-mimicking lesion.

Pubmed   Journal   ReadQx 

Tornado cleaning technique for food impaction in gastroduodenal stent using a high-rotational spiral basket catheter.

Pubmed   Journal   ReadQx   PMC

Traction clip closure of small bowel perforation during single-balloon enteroscopy in a patient with surgical altered anatomy.

Pubmed   Journal   ReadQx 

Transrectal endoscopic resection of intraperitoneal gastrointestinal stromal tumor facilitated by incidental segmental absence of intestinal musculature.

Pubmed   Journal   ReadQx   PMC

Video capsule endoscopy identifies severe small bowel lesions in a pediatric case of Henoch-Schönlein Purpura.

Pubmed   Journal   ReadQx 

Will conventional endoscopic submucosal dissection disappear or be rescued from the water by saline immersion?

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A novel endoscopic closure using interconnected rubber rings combined with clips for colorectal mucosal defects after endoscopic submucosal dissection (with video).

Pubmed   Journal   ReadQx 

Best of Colonoscopy in 2025.

Pubmed   Journal   ReadQx 

Best of EGD 2025.

Pubmed   Journal   ReadQx 

Diagnosis of gastric mucosa-associated lymphoid tissue lymphoma by EUS-guided through-the-needle biopsy (with video).

Pubmed   Journal   ReadQx 

EUS-guided Gallbladder Drainage Combined with ERCP for Severe Pancreatitis Complicated by Acute Obstructive Suppurative Cholangitis and Calculous Cholecystitis.

Pubmed   Journal   ReadQx 

Intravenous Dextrose During Emergence from Deep Sedation Reduces Postprocedural Dizziness in Adults Undergoing Gastrointestinal Endoscopy: A Randomized Controlled Trial.

Pubmed   Journal   ReadQx 

Peroral cholangioscopy facilitates successful management of post-EUS biliary drainage stent obstruction.

Pubmed   Journal   ReadQx 

Top Tips: Endoscopic Management of Gastric Outlet Obstruction.

Pubmed   Journal   ReadQx 

Gut

Artificial intelligence-tailored bowel preparation reduces laxative burden and promotes sustainable endoscopy.

Pubmed   Journal   ReadQx 

Unravelling the heterogeneous HCC risk in indeterminate chronic hepatitis B.

Pubmed   Journal   ReadQx 

Hepatology

Betaine in the treatment of steatotic liver disease-Historical fad or a timeless treasure worth reviving?

Pubmed   Journal   ReadQx 

Hepatic stellate cells and macrophages: Key players in HCC immune suppression.

Pubmed   Journal   ReadQx 

Honey, I shrunk the tumor: Downstaging HCC before liver transplantation.

Pubmed   Journal   ReadQx 

Letter to the Editor: Peripheral Foxp3-high Tregs as a dual biomarker for HCC prognosis and Immunotherapy response.

Pubmed   Journal   ReadQx 

Letter to the Editor: The treatment options for de novo perihilar cholangiocarcinoma require more details.

Pubmed   Journal   ReadQx 

Reply: The CRAPT-M score: Robust enough for clinical practice?

Pubmed   Journal   ReadQx 

Reply: The treatment options for de novo perihilar cholangiocarcinoma require more details.

Pubmed   Journal   ReadQx 

SMART Steps to HBV Cure.

Pubmed   Journal   ReadQx 

Surging sludge: Intrahepatic cholangiocarcinoma mortality on the rise worldwide.

Pubmed   Journal   ReadQx 

Unlocking immunity's memory: Epigenetic keys to HBV control.

Pubmed   Journal   ReadQx 

J Hepatol

From gut to brain - and back again: A new paradigm of adaptive immune surveillance with implications for liver disease.

Pubmed   Journal   ReadQx 

From the Editor's Desk...

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky. Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Does Metabolic Dysfunction-Associated Steatotic Liver Disease With Advanced Fibrosis Also Equate to Risk of Advanced Coronary Artery Disease? Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Dual Advanced Therapy in Refractory Ulcerative Colitis-Hope Beyond Monotherapy. Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Intestinal Ultrasound for the Assessment of Constipation-Out of the Shadows? Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Redefining Decompensation in Cirrhosis-More Than an Academic Playground? Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Redefining Safety in Post-Liver Transplant IBD-Why Therapeutic Effectiveness Is the Ultimate Shield. Authors' Reply.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

ALT and novel fibrosis scores for risk stratification of pediatric MASLD.

Pubmed   Journal   ReadQx 

Advancing Proactive Therapeutic Drug Monitoring with Model-Informed Precision Dosing in Pediatric Crohn's Disease.

Pubmed   Journal   ReadQx 

Clarifying the Link Between IMO and Constipation.

Pubmed   Journal   ReadQx 

Symptom differences in IMO vs SIBO - is EPI the missing link?

Pubmed   Journal   ReadQx 

Gastroenterology

Clarifying the Biological Specificity of Dietary Fiber Effects in Celiac Disease Risk: Mechanistic Precision Matters.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Colorectal cancer screening from the standpoint of sequential versus simultaneous approaches: insights from the Danish national screening program.

Pubmed   Journal   ReadQx 

Evaluating the incidence and risk factor analysis of 30-day hospital admission after high-risk outpatient endoscopic retrograde cholangiopancreatography.

Pubmed   Journal   ReadQx 

Occurrence of gastric cancer in patients with juvenile polyposis syndrome.

Pubmed   Journal   ReadQx 

Gut

EUS-guided portal pressure measurement: how to make it more accurate?

Pubmed   Journal   ReadQx 

Real-world validation of a prognostic clinical index to predict steroid response in acute severe colitis: a single tertiary centre retrospective study.

Pubmed   Journal   ReadQx